| 91 | 21 | 45 |
| 下载次数 | 被引频次 | 阅读次数 |
研究海脉冲营养素“HMC”对小鼠免疫功能的影响。结果表明:小鼠口服HMC300mg/kg·d,连续7~10d,可增加小鼠免疫器官的重量(P<0.05);提高小鼠腹腔巨噬细胞吞噬率和吞噬指数(P<0.01);促进PHA刺激的淋巴细胞转化反应(P<0.01)和提高ANAE+淋巴细胞百分率(P<0.05);对小鼠血清溶血素和PFC数目的生成无显著影响(P>0.05),对HPA和CTX引起的免疫抑制有拮抗作用。提示:HMC是一种有效的免疫调节剂。
Abstract:The effects of HMC on mouse immune functions are studied. The results show that, given orally at the dose of 300mg/kg×7 or 10d, HMC can increase the weight of immunological organs (P<0.05), the phagocytic rate and index (P<0.01) of the murine peritoneal macrophage. The percentage of ANAE + lymphocytes (P<0.05) and lymphocyte transformation (P<0.01) induced by PHA are also enchanced. Meanwhile there are no marked potentiating effects on the production of serum hemolysin and PFC (P>0.05) in mice immunized with SRBC, and with the antagonistic effect on the immunosuppression induced by HPA or CTX. The results suggest that HMC is an effective immunomodulatory drug which can protect and potentiate both the specific and nonspecific immune function in mice.
1徐淑云,等编.药理实验方法学.北京:人民卫生出版社,1985.934~9452姜世勃,陈泽洪,李文简.T淋巴细胞酯酶活性检测法的改进及其影响因素.上海免疫学杂志,1983,3(4):2543李仪奎,等编.中药药理实验方法学.上海:上海科学技术出版社,1991.155~1594边棣,李观海,张洪泉.去氢骆驼蓬碱对小鼠免疫功能的影响.中国药理学报,1987,8(5):477~4805史美浩,马宝骊,余氵贺.新生小鼠胸腺细胞免疫抑制功能探讨.上海免疫学杂志,1981,1(1):16高海谦.增强免疫功能的中草药.中成药研究,1984,11:347徐文玉.营养素与免疫和癌.上海免疫学杂志,1989,9(3):1818陈先农.营养对机体免疫功能的影响.免疫学快报,1988,8(1、2):679杨藻宸.医用药理学.北京:人民卫生出版社,1994.100710上海第一医学院主编.医用生物化学.北京:人民卫生出版社,1979.172~179
基本信息:
DOI:10.16441/j.cnki.hdxb.1997.04.015
中图分类号:R979.5
引用信息:
[1]王静凤,胡京滨,李立德,王其户.海脉冲营养素(HMC)研究——HMC对小鼠免疫功能的影响[J].青岛海洋大学学报,1997(04).DOI:10.16441/j.cnki.hdxb.1997.04.015.
基金信息:
山东省科委资助
1997-10-15
1997-10-15