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海洋无脊椎动物缺乏真正意义上的抗体,没有免疫记忆,只能靠非特异性免疫系统防御和抵抗病原体的感染。酚氧化酶原激活系统是海洋无脊椎动物非特异性免疫系统中至关重要的一员,而酚氧化酶作为该系统末端的一种含铜金属酶,则通过催化黑化反应在海洋无脊椎动物非特异性免疫防御中发挥了关键的作用。本文结合作者已有的研究成果并综合本领域的大量参考文献对酚氧化酶原激活系统和酚氧化酶的免疫学功能、激活机制、生化性质与酶性质以及基因与分子结构等方面的研究进展进行综述。
Abstract：Marine invertebrates lack the true meaning of the antibodies and immune memory and have to resist pathogen infection with non-specific immune system.Prophenoloxidase-activating system is one of the most important components of the non-specific immune system in marine invertebrates,but0 phenoloxidase,as a terminal copper-containing metalloenzyme in this system,plays a key role in the non-specific immune defense of marine invertebrates by catalyzing melanization.In this paper,the research advances on immunological function,activation mechanism,biochemical and enzymatic properties,as well as gene and molecular structure of PO and proPO-AS are reviewed based on our research achievements and a large number of academic literatures in this field.
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基本信息:
DOI：10.16441/j.cnki.hdxb.2012.z1.015
中图分类号:Q55
引用信息:
[1]樊廷俊,荆昭,樊现远.海洋无脊椎动物酚氧化酶的研究进展[J].中国海洋大学学报(自然科学版),2012,42(Z1):93-98+168.DOI:10.16441/j.cnki.hdxb.2012.z1.015.
基金信息:
教育部骨干教师资助计划项目(160004)资助
2012-01-15
2012-01-15