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本研究报道了具有抗螨虫活性的天然产物AB3217A及其衍生物的模块化合成。以易得的茴香霉素和D-木糖硫苷衍生物为起始原料，通过木糖C2位苯甲酸酯的邻基参与效应调控的立体选择性木糖β-糖苷键的形成和DDQ(2,3-二氯-5,6-二氰基-1,4-苯醌)介导的分子内交叉脱氢醚化反应作为关键步骤，经9—10步反应以5.6%～8.9%的总收率实现了AB3217A及其结构类似物的合成，从而为其生物活性研究奠定了物质基础。
Abstract：A modular synthesisof AB3217A with antimite activity and its analogues has been achieved. The synthesis uses the readily accessible anisomycin and D-thioxylofuranoside derivative as the starting materials, and involves stereoselective β-xylofuranosidic bond construction directed by the neighboring group participation of the C2-benzoate in the xylofuranosyl residue, and a DDQ-promoted intramolecular cross-dehydrogenative etherification reaction as the key transformations. Through this integrated approach, AB3217A and its structural analogues were successfully synthesized in 9 to 10 steps sequence with overall yields of 5.6%～8.9%, thereby establishing a foundation of material basis for biological evaluation in future.
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基本信息:
DOI：10.16441/j.cnki.hdxb.20250135
中图分类号:O629
引用信息:
[1]孙超民,王自强,王鹏,等.AB3217A及其衍生物的模块化合成[J].中国海洋大学学报(自然科学版),2026,56(05):113-119.DOI:10.16441/j.cnki.hdxb.20250135.
基金信息:
国家自然科学基金项目(22377114); 青岛海洋科技中心专项经费(2022QNLM030003-2)资助~~
2026-04-27
2026-04-27