石杰,庄安士,张雪玲

• 1:中国海洋大学海洋药物与食品研究所
• 2:青岛市立医院药物研究室
• 3:青岛市立医院药物研究室 山东青岛266003
• 4:青岛市立医院药物研究室

摘要(Abstract)：

研究海洋药物911,971对大鼠CYP2E1是否有抑制或诱导作用,以及这种作用是否具有性别差异。取大鼠,雌雄各半,随机分为6个组:Ⅰ)雄性对照组、Ⅱ)雄性911组、Ⅲ)雄性971组;Ⅳ)雌性对照组、Ⅴ)雌性911组、Ⅵ)雌性971组,均采用钙离子沉淀法制备肝微粒体。在各组肝微粒体中同时给予一定剂量的探针药物及目标药物,进行孵育,于不同时间点取样,测定该探针药物的剩余浓度并计算其体外半衰期。结果表明:药物911对CYP2E1活性无影响,971对雌性大鼠CYP2E1活性无影响,但对雄性大鼠的CYP2E1有显著诱导作用。由此可得出:药物对CYP2E1的影响存有明显的性别差异,971在同各种与CYP2E1代谢有关的药物合用时,应充分考虑其在不同性别间的差异,以避免可能出现的毒性反应或不良反应。

关键词(KeyWords)： 海洋药物;氯唑沙宗;CYP2E1

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 石杰,庄安士,张雪玲

DOI: 10.16441/j.cnki.hdxb.2005.03.027

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