刘红霞,尹志伟,王诗玺,万升标,江涛

• 1:中国海洋大学医药学院海洋药物教育部重点实验室
• 2:齐齐哈尔大学化学与化学工程学院

摘要(Abstract)：

以2,6-二氯嘌呤为原料,微波辐射法合成了"Reversine"[1,2-(4-吗啉苯胺基)-N6-环己基腺嘌呤]的重要中间体2-氯-6-环己胺基嘌呤及其衍生物3b～3f,再以2-氯-6-环己胺基嘌呤为原料,微波辐射下合成了2-苯胺基-6-环己胺基嘌呤及"Reversine"。探索了合适的反应条件及影响因素,产物的结构通过1 H NMR进行了表征。研究表明,微波法可大幅提高合成嘌呤2,6位衍生物收率并缩短反应时间,为嘌呤衍生物及"Reversine"的合成提供了一种绿色、简洁高效的合成方法。

关键词(KeyWords)： 微波;嘌呤;Reversine;合成

Abstract:

Keywords:

基金项目(Foundation): 国际合作项目(2009DFA32080)资助

作者(Author): 刘红霞,尹志伟,王诗玺,万升标,江涛

DOI: 10.16441/j.cnki.hdxb.2013.09.013

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